Lab Tests Diagnostic Medical Tests Medical Lab Tests
 Red blood cell count
 Red cell indices
 sedimentation rate
 Reticulocyte count
 Osmotic fragility
 Total hemoglobin
 Fetal hemoglobin
 Sickle cell test
 Unstable hemoglobin
 Heinz bodies
   Iron and total
 iron-binding capacity
 White blood cell count
   White blood cell
 Bleeding time
 Platelet count
 Capillary fragility
 Platelet aggregation
   Activated partial
 thromboplastin time
 Prothrombin time
 Activated clotting time
   One-stage factor
 coagulation system
   One-stage factor
 coagulation system
 Plasma thrombin time
 Plasma fibrinogen
 Fibrin split products
 Plasma plasminogen
 Protein C
 Euglobulin lysis time
 normalized ratio

Home :: Plasma thrombin time

Plasma Thrombin Time

Plasma thrombin time, or thrombin clotting time, measures how quickly a clot forms when a standard amount of bovine thrombin is added to a platelet poor plasma sample from the patient and to a normal plasma control sample After thrombin is added, the clotting time for each sample is compared and recorded. This test allows a quick but imprecise estimation of plasma fibrin ogen levels.


  • To detect fibrinogen deficiency or defect
  • To aid diagnosis of disseminated intravascular coagulation (DIC) and hepatic disease.
  • To monitor the effectiveness of treatment with heparin or thrombolytic agents.

Patient preparation

  • Explain to the patient that this test is used to determine if blood clots normally.
  • If possible, withhold heparin therapy before the test. If heparin must be continued, note this on the laboratory slip.
  • Tell the patient that a blood sample will be taken. Explain who will perform the venipuncture and when.
  • Reassure him that drawing a blood sample will take less than 3 minutes.
  • Explain that he may feel slight discomfort from the tourniquet pressure and the needle puncture.
  • Inform the patient that food or fluids need not be restricted before the test.

Procedure and posttest care

  • Perform a venipuncture, and collect the sample in a 7-ml blue-top tube.
  • If a hematoma develops at the venipuncture site, apply warm soaks.
  • If t he tube isn't filled to the correct volume, an excess of citrate appears in the sample. Completely fill the collection tube, and invert it gently several times to mix the sample and the anticoagulant thoroughly.
  • To prevent hemolysis, avoid excessive probing during venipuncture and rough handling of the sample.
  • Immediately send the sample on ice to the laboratory.

Reference values

Normal thrombin times range from 7 to 12 seconds. Test results are usually reported with a normal control value.

Abnormal findings

A prolonged thrombin time may indicate heparin therapy, hepatic disease, DIC, hypofibrinogenemia, or dysfibrinogenemia. Patients with prolonged thrombin times may require measurement of fibrinogen levels; in suspected DIC, the test for fibrin split products is also necessary.

Interfering factors

  • Failure to use the proper anticoagulant, to adequately mix the sample and the anticoagulant, or to send the sample to the laboratory immediately.
  • Hemolysis due to rough handling of the sample or to excessive probing at the venipuncture site.
  • Fibrinogen level < 100 mg/d1 (prolonged thrombin time)
  • Fibrinogen inhibitors, such as streptokinase, urokinase, and tissue plasminogen activators cenforce bez recepty (increase).
  • Heparin (possible increase).

Diagnostic Medical Tests
Medical Tests
Dagnostic Tests
Lab Tests

Contact us | Link to us | Lab tests
Resources - 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
(c)Copyright All rights reserved.

The information provided on this web site should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. We will not be liable for any complications, or other medical accidents arising from the use of any information on this web site.